if your mouse is not working then there are some steps to follow-
Reboot the computer to resolve this issue.
disconnect the mouse cable and then reconnect to a different USB port.
try to change your mouse or change your port.
clean your mouse.
Right Click My Computer
then click on PropertiesDevice Manager Look for universal serial bus/usb drivers/other devices.
uninstall USB devices by right click and unistall the device
restart the computer
let USB reinstall ..
try to troubleshooting
click on start and in the search bar type trobleshooting and under system and security
click on run maintenance task and follow instrustion after that click on Fix problem with windows update.
delete some temp file and clean your computer from the viruses, spyware, junks, cookies, koobface..
i hope this will help you out.